Peripheral Oxyntomodulin Reduces Food Intake and Body Weight Gain in Rats

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Peripheral oxyntomodulin reduces food intake and body weight gain in rats.

Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from cells of the gastrointestinal mucosa. Given intracerebroventricularly to rats, it inhibits food intake and promotes weight loss. Here we report that peripheral (ip) administration of OXM dose-dependently inhibited both fast-induced and dark-phase food intake without delaying gastric emptying. Peripheral OXM administr...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 2004

ISSN: 0013-7227,1945-7170

DOI: 10.1210/en.2003-1338